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KMID : 0858420060080020187
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Korean Journal of Stroke
2006 Volume.8 No. 2 p.187 ~ p.190
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Acute Reactive Protein in the Cerebral Small-vessel Occlusion
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Sung Young-Hee
Shin Dong-Jin
Park Hyeon-Mi
Lee Yeong-Bae
Park Kee-Hyung
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Abstract
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Background: Inflammatory processes are implied in the pathogenesis of atherosclerosis and are a risk factor for myocardial infarction, stroke, and peripheral arterial disease. We assessed whether acute reactive protein such as C-reactive protein (CRP) and fibrinogen levels are related to small-vessel occlusion.
Methods: Six hundred twelve patients with acute ischemic stroke and one hundred thirteen control subjects who visited Gil Medical Center between March 2004 and February 2005 were enrolled in this study. Acute ischemic stroke was classified by TOAST classification. Among these patients, large artery disease (LAD), small vessel occlusion (SVO) patients uncomplicated by infection were included, and cardioembolic (CE), stoke of others determined cause (SOD) and stoke of undetermined etiology (SUE) were excluded. CRP and fibrinogen were measured during the first 48 hours after stroke onset. We analyzed the risk factor and acute reactive protein in each group.
Results: Among the 612 patients with acute ischemic stroke patients, 235 had LAA and 213 had SVO. There was no significant difference in clinical characteristics between groups. LAA group had higher CRP and fibrinogen levels than SVO or control group. The CRP level was higher in SVO group than control group (p=0.041), but the fibrinogen showed no significant difference between two groups (p=0.302).
Conclusion: The CRP may be involved in the pathophysiology of small-vessel occlusion as well as large-artery atherosclerosis. (Korean Journal of Stroke 2006;8:187-190)
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KEYWORD
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Small-vessel occlusion, CRP, Fibrinogen
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